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| Year : | 2006 |
| Tome : | 157 |
| Volume : | 12 |
| Pages : | 573-578 |
| Title : | Canine herpes virus infection : evaluation of vaccine efficiency (inactive vaccine) in reproductive bitches with 2 different protocols, field trial. |
| Authors : | A. CHABCHOUB, F. KALLEL, S. HADDAD, F. LANDOLSI, M. RMILI ET F. VAN GOOL |
| Summary : | A medical prophylaxis against canine herpes virus infection was carried out in canine centre using EURICAN®Herpes205 virus vaccine (Merial Laboratory). This study aims to estimate vaccine efficiency by observing the neonate mortality and anatomopathological lesions in autopsy. For that, 23 females (mean age : 3.60 ± 1.19 years) were randomly divided into 3 groups : in the first group, females (n = 6) were not vaccinated and were used as positive controls ; in the 2 other groups, females received only one subcutaneous vaccine injection at the end of the gestation (group 2, n = 10) or 2 injections at the beginning and at the end of the gestation (group 3, n = 7). The 3 groups were comparable in terms of age and breed as well as for herpes virus serological status (The CHV1 seroprevalence was comprised between 28.57 to 33.33 %). According to the necropsy of puppies, the CHV1 was responsible for a high mortality in the control group and vaccination has induced a significant reduction of the neonate mortality (p < 0.05), particularly when females have received 2 vaccine injections (group 2 vs. group 3 : p < 0.05). The average neonate mortality calculated by litter was also significantly lowered on the overall vaccinated female populations (p < 0.05) and also on the seropositive mothers. These results show the beneficial interest of medical prophylaxis based on a complete vaccine protocol in canine centres where herpes virus infection occurs. |
| Keywords : | herpes virus infection, vaccine efficiency, dog, Tunisia, neonate mortality |
| Correspondence : | A. CHABCHOUB |
| Adress : | Ecole vétérinaire Sidi-Thabet 2020 TUNISIE Tél. : 0021671552200, Fax : 0021671552441, Email : chabchoubahmed2001@yahoo.fr, ou chabchoub.ahmed@iresa.agrinet.tn |
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